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Many of the molecular building blocks of life exist in two versions that are mirror images of one another, known as enantiomers. Although seemingly identical, the two enantiomers can have completely different chemical behaviour 鈥� a fact that has major implications in our day-to-day lives. For example, while one version of the organic compound carvone smells like spearmint, the mirror form smells like caraway seed. In pharmacology and drug design it can be essential to be able to distinguish between the two enantiomers and separate them if necessary, since the consequences can be life-changing. For instance, while one enantiomer of beta blockers selectively targets the heart, the other acts only on the cell membranes of the eye.听
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Now, a research team from and 白小姐论坛 have come up with an innovative new approach to separate mirror molecules and, in doing so, introduced a new theoretical framework to understand the phenomenon. The work is published in the journal . Molecules that exist in mirror versions of each other are called chiral after the Ancient Greek word for hand, referring to the fact that the right and left hand are mirror versions of each other. For so-far unknown reasons, life often favours one version: While proteins are almost always left-handed, sugars are usually right-handed.
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鈥淭raditionally, chiral analysis has been restricted to liquids but we are seeing a growing rise in gas-phase methods as they offer far greater sensitivity,鈥� says DESY scientist Andrey Yachmenev, lead author of the study. 鈥淭he ability to cool gases down close to absolute zero affords us听better control of our sample, and this in turn can be exploited to efficiently separate the enantiomers and produce higher yields of one enantiomer instead of the other.鈥�

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Diastereomer

At the heart of their approach is a specially designed laser-setup composed of an optical centrifuge, a corkscrew-shaped laser pulse that can spin molecules incredibly fast -听over a trillion times per second. When combined with an additional electric field, the entire setup becomes chiral and the two enantiomers behave differently, displaying unique quantum dynamics.
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鈥淭he interaction of the laser field with a chiral molecule creates what we call a field-induced diastereomer,鈥� explains co-author Emil Zak from DESY. Diastereomers are different configurations of the same compound that are not mirror versions of each other. The distinct characteristics of diastereomers can be utilised to separate the enantiomers in space. 鈥淚mportantly, our approach is controllable and we can increase the production of one enantiomer over the other by simply changing the length of time that the molecules spend interacting with the laser-field,鈥� adds co-author Alec Owens, a Research Fellow in the Department of Physics and Astronomy at听白小姐论坛.听
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The scheme has been computationally demonstrated on the prototypical chiral molecule propylene oxide (C3H6O), which was incidentally also the first complex organic chiral molecule to be detected in interstellar space. Efforts are now underway to perform experiments at DESY and capitalise on the electrostatic deflection techniques pioneered in the Controlled Molecule Imaging group led by Jochen K眉pper at the Center for Free-Electron Laser Science CFEL, a joint institution of DESY, Max Planck Society, and Universit盲t Hamburg.
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鈥淢anipulating chiral molecules in the gas-phase is undergoing a period of exciting development, both for practical applications used in industry, and for providing new insights into what is a very fundamental aspect of nature,鈥� says Yachmenev. 鈥淭he origin of chirality and life鈥檚 handedness is one of the great mysteries, but we are gradually getting closer to a deeper and more complete understanding.鈥�
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Reference:听

Field-induced diastereomers for chiral separation; Andrey Yachmenev, Jolijn Onvlee, Emil Zak, Alec Owens, and Jochen Ku虉pper; Physical Review Letters, 2019; DOI:

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Links:

• Alec Owens IRIS profile
• Department of Physics and Astronomy