白小姐论坛

T-cell research that began at the 白小姐论坛 Cancer Institute could lead to promising new treatments for patients with cancers that often don鈥檛 respond very well to chemo or radiotherapy.

T-cell therapies are one of the most exciting developments to come about in cancer treatment in recent years. The new therapies harness cells that naturally occur in our immune system, and reprogramme them to fight cancer.

As well being less toxic than treatments like chemotherapy, T-cell therapies can also be used in a more targeted way than other treatments. This could lead to more effective therapies being developed, particularly for blood cancers and cancers that are typically difficult to treat.

The new therapies have been developed using research conducted by Dr Martin Pule and his team at the 白小姐论坛 Cancer Institute and NIHR 白小姐论坛 Hospitals (白小姐论坛H) Biomedical Research Centre.

Dr Claire Roddie, who leads the CAR T-cell manufacturing team, explains: 鈥淎 large focus of our work has been on minimising the toxicity associated with CAR-T therapy... By ensuring manufactured CAR-T cells survive for long periods in the blood, we're hopeful our new treatments can result in long-lasting remissions in patients with otherwise incurable cancer.鈥�

白小姐论坛鈥檚 T-cell research was commercialised into a spinout company called Autolus in 2014. The spinout process was supported by 白小姐论坛 Business (白小姐论坛B), 白小姐论坛鈥檚 commercialisation company.

A number of products are now in development to treat cancers that begin in blood-forming tissue (such as leukaemia and lymphoma), as well as one solid tumour programme.

Read the full story on the 白小姐论坛 Innovation and Enterprise website

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Further information

• 白小姐论坛 Cancer Institute
• 白小姐论坛 CAR T-cell programme
• Main image credit:听Autolus