白小姐论坛

XClose

白小姐论坛 Division of Medicine

Menu

Fibrosis and Tissue Repair

One of our concerns at the Institute for Liver and Digestive Health is tissue repair. Our current research interest is fibrogenesis with focus on Hepatic Stellate Cell behaviour in liver fibrosis and liver cancer cell biology with a specific focus on fibrotic stroma - cancer cell interaction.

Researchers have begun to grow new livers from rejected donor organs in a breakthrough that could transform transplantation surgery.

Engitix announces new agreement to develop therapies for IBD

Dr Giuseppe Mazza鈥檚 firm signs expanded agreement with Takeda for the discovery and development of novel therapeutics for inflammatory bowel disease (IBD).

Our work听

Our current research interest is fibrogenesis with focus on Hepatic Stellate Cell behaviour in liver fibrosis and liver cancer cell biology with a specific focus on fibrotic stroma - cancer cell interaction.听Further interests include genetic polymorphism heterogeneity - cell behaviour in diseases such as Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis and cancer development.

The Team鈥檚 research remit covers both identifying/characterization of human organ specific Extracellular Matrix and cellular components of tissues, with a specific focus on cell behaviour in 2D and 3D cell culture systems for improvement of new target identification and drug development.听

Together with the ENETS oncology team of the Royal Free Hospital we are exploring mesenteric fibrosis in small intestinal neuroendocrine tumours:

  • pathogenesis and potential therapeutic targets
  • early biomarker detection in mesenteric fibrosis
  • Deep Sequencing of gastroenteropancreatic neuroendocrine carcinoma.

YouTube Widget Placeholder

Our experts

Professor Krista Rombouts

(Lead)
Professor of Experimental Hepatology

Professor Massimo Pinzani


Emeritus Professor

Professor Giuseppe Massa


Honorary Associate Professor

Dr Walid Al-Akkad Abu-Zeina


Honorary Research Fellow

Marlon Lemos Dias

Marlon Lemos Dias
International Researcher

Dr Peng Dai

Dr Peng Dai
Research Fellow

Basic silhouette in a circle, in light grey

Dr Yan Jun
Research Fellow

Basic silhouette in a circle, in light grey


Research Assistant

NHS collaborators

Professor Martyn Caplin


Gastroenterology &听neuroendocrine

Professor Christos Toumpanakis


Gastroenteorology &听neuroendocrine

Dr Daniel Krell


Consultant medical oncologist

Dr Conrad von Stempel


Interventional vascular & uroradiologist

Dr Amir Gander

Dr Amir Gander
HTA Designated Individual,听Tissue Access

Basic silhouette in a circle, in light grey

Dr Dalvinder S. Mandair

PhD students

  1. Maria In锚s Castanho Martins
  2. Saiji Kathiresu Nageshwaran
  3. Giulia Lupo

听

Selected publications

  1. Al-Akkad W, Acedo P, Vilia MG ...听Hall AR ...听Luong TV, Whittaker SR, Pereira SP,听Vallier L, Pinzani M, Rombouts K, Mazza G (2022). . Cells. 2022 Nov 17;11(22):3652.

  2. Thanapirom K, Caon E, Papatheodoridi M, Frenguelli L, Al-Akkad W, Zhenzhen Z, Vilia MG, Pinzani M, Mazza G, Rombouts K (2021). . Cancers (Basel). 2021 Sep 30;13(19):4936.

  3. Laskaratos FM, Levi A, Schwach G, Pfragner R, Hall A, Xia D, von Stempel C ...听Luong TV, Toumpanakis C, Mandair D, Caplin M, Rombouts K (2021).听. Frontiers Oncology. 2021 Feb 24;11:629665. eCollection 2021.

  4. Dat NQ, Thuy LTT, Hieu VN ...听Rombouts K, Dong MP, Hanh NV ...听Pinzani M, Kawada N (2021). . Hepatology. 2021 Jun;73(6):2527-2545.听Epub 2021 May 22. Erratum in: Hepatology. 2022 Dec;76(6):1902.

  5. B枚ttcher K, Longato L, Marrone G, Mazza G, Ghemtio L, Hall A, Luong TV, Caruso S, Viollet B, Zucman-Rossi J, Pinzani M, Rombouts K (2021).听. Am J Physiol Gastrointest Liver Physiol. 2021 Apr 1;320(4):G543-G556.

  6. Pavlovi膰 N, Calitz C, Thanapirom K, Mazza G, Rombouts K, Gerwins P, Heindryckx F (2020). . Elife. 2020 Oct 26;9:e55865.

  7. Zanieri F, Levi A, Montefusco D ...听Luong TV听...听Mazza G, Argemi J, Bataller R, Cowart LA, Kester M, Pinzani M, Rombouts K (2020).听. Cells. 2020 May 16;9(5):1237.

  8. Okina Y, Sato-Matsubara M, Matsubara T, Daikoku A, Longato L, Rombouts K ...听Pinzani M, Kawada N. . Journal of Hepatology. 2020 Apr 17. pii: S0168-8278(20)30228-2.

  9. Barcena-Varela M, Paish H, Alvarez L ...听Rombouts K, Oakley F, Mann J, et al (2020).听. Gut. 2020 Apr 23. pii: gutjnl-2019-320205.

  10. Kostrzewski T, Maraver P, Ouro-Gnao L, Levi A, Snow S, Miedzik A, Rombouts K*, Hughes D* (2019). . Hepatology Communication. 2019 Nov 13;4(1):77-91.听eCollection 2020 Jan. (*Contributed equally)

  1. Mazza G, Telese A, Al-Akkad W, Frenguelli L, Levi A ...听Hall AR, Godovac-Zimmermann J, Luong TV, De Coppi P, Pinzani M, Rombouts K听(2019).听. Cells. 2019 Dec 28;9(1). pii: E83.

  2. Laskaratos FM, Mandair D, Hall A, Alexander S, von Stempel C, Bretherton J, Luong T, Watkins J, Ogunbiyi O, Rombouts K, Caplin M, Toumpanakis C听(2020). . Endocrine. 2020 Mar;67(3):718-726.

  3. De Chiara F, Thomsen KL, Habtesion A ...听Hall A, Andreola F, Paish HL, Reed LH, Watson AA, Leslie J, Oakley F, Rombouts K, et al听(2020). . Hepatology. 2020 Mar;71(3):874-892.

  4. Giuffrida P, Curti M, Al-Akkad W, Biel C, Crowley C, Frenguelli L, Telese A, Hall A ...听Pinzani M, Di Sabatino A, *Rombouts K, *Mazza G听(2019).听. Inflamm Bowel Dis. 2019 Oct 18;25(11):1740-1750.听(*Contributed equally.)

  5. Marrone G, De Chiara F, B枚ttcher K, Levi A, Dhar D, Longato L, Mazza G, Zhang ZZ, Marrali M, Fern谩ndez-Iglesias A, Hall A, Luong TV, Viollet B, Pinzani M, Rombouts K (2018). . Hepatology. 2018 Sep;68(3):1140-1153.

  6. B枚ttcher K, Rombouts K, Saffioti F, Roccarina D, Rosselli M, Hall A, Luong TV, Tsochatzis EA, Thorburn D, Pinzani M (2018).听. Hepatology. 2018 Jul;68(1):172-186.

  7. Mazza G, Al-Akkad W, Telese A, Longato L, Urbani L, Robinson B, Hall A听...听Rombouts K, Pinzani M (2017). . Scientific Report. 2017 Jul 17;7(1):5534. PubMed PMID: 28717194

  8. Carloni V, Lulli M, Madiai S, Mello T, Hall A, Luong TV, Pinzani M, *Rombouts K, *Galli A (2017).听. Gut. 2018 Feb;67(2):348-361.

  9. Longato L, Andreola F, Davies SS, Roberts JL, Fusai G, Pinzani M, Moore K, Rombouts K (2017). . Free Radic Biol Med. 2017 Jan;102:162-173.

  10. Jalan R, De Chiara F, Balasubramaniyan V, Andreola F, Khetan V, Malago M, Pinzani M, Mookerjee RP, Rombouts K (2016). . Journal of Hepatology. 2016 Apr;64(4):823-33.

Funding and partnerships

Logo for European Crohn's and Colitis Organisation (ECCO)

European Crohn's and Colitis Organisation

Logo for Neuroendocrine Tumour Research Foundation. NET in cyan, with microscope wrapped through the N

Neuroendocrine Tumor Research Foundation

Logo for NIHR | 白小姐论坛 Hospitals Biomedical Research Centre

NIHR 白小姐论坛 Hospitals BRC

Logo for UKRI Innovate UK (navy / pink)

Technology Strategy Board (Innovative UK)

Royal Free Charity logo

Royal Free Charity

Logo for the Fiorina Foundation, part of the Royal Free Charity. A coastal scene.

Fiorina Foundation

Logo for CN Bio Innovations

Industrial Partners: CNBio Innovations

Logo for DefiniGEN Disease Model Innovation

Industrial Partners:听DefiniGEN Ltd

Related programmes

Our members contribute to the MBBS, iBSc, BSc and master鈥檚 degrees within the Division of Medicine. We provide BSc and MSc/MRes research project supervision. We also have an established track record in providing high-quality training to PhD students interested in basic, translational, and clinical research in the areas of liver, pancreas, and biliary diseases.

Interested in joining us?

Researchers: We welcome prospective applications from talented postdoctoral candidates seeking to obtain their own funding. To discuss potential opportunities, please contact Prof. Krista Rombouts (k.rombouts@ucl.ac.uk). Please include the following documents and information:

  • CV
  • Short description of the research questions you would like to address (no more than half an A4 page)
  • Funding scheme(s) you would like to apply for and deadline(s) for submission.

Students: If you have a good academic record, are interested in a career in biological science or academic medicine and would like to discuss opportunities in ILDH, please contact the Principal Investigator or Senior Research Associate whose research area most interests you.

Contact details

Address

Division of Medicine, Institute for Liver and Digestive Health 听
白小姐论坛 Medical School
Upper 3rd Floor Royal Free Hospital
LONDON
NW3 2QG