Urological Biology
Our work
Bladder diseases have been historically understudied. We look at two key areas: recurrent / treatment-resistant urinary tract infection (UTI) and urothelial cancers.聽Both have suffered from a lack of human cell-based models to provide insights that experimental animals cannot.
In addition to studying the basic biology, we build innovative new microtissue models and develop novel therapies, in broad interdisciplinary collaborations across cell biology, microbiology, computational genetics, medicine, biomedical engineering, materials science and mathematics, spanning academia, industry and the clinic.
Research themes include:
- Tissue engineering and on-chip microfluidic platforms
- Molecular human cell biology
- Host / pathogen interactions of recurrent UTI in various populations, including older individuals and immunosuppressed renal transplant patients
- Antimicrobial resistance
- Pathogen genomic variation in vivo, including within the urinary microbiota
- Biofilms
- Novel drug delivery systems
- Epithelial innate immunity, urothelial biology and urothelial cancers.
Prof. Jennifer Rohn,听Claudio Del Fatti and Damien Richard talk about their research, while chronic UTI patient Helen explains why it鈥檚 such a terrible disease.
Our experts
听(贬别补诲)
Professorial Research Fellow
聽(Deputy Head)
Honorary Associate Professor
Dr Gillian Smith
RFL Group Chief Medical Officer
Professor of Renal Transplantation
Group members
Nicholas Yuen
Victoria Chu
Selected Publications
- 贵濒辞谤别蝉听颁, Ling聽J, Loh聽A, Garcia Maset聽R, Aw聽A, White聽IJ, Fernando聽R,听搁辞丑苍听闯尝 (2023).听. BioRxiv.
- Stride聽E, Choi聽V, Carugo聽D, 搁辞丑苍听闯尝, Stoodley聽P聽(2023). . Nature Reviews Microbiology.
- 闯补蹿补谤颈听狈痴,听Rohn JL (2023).听. Frontiers in Infection Cell Microbiology, 13, 269.
- Lasri Doukkali聽A, Lorenzi聽T, Parcell聽BJ, 搁辞丑苍听闯尝, Bowness聽R聽(2023). . Frontiers in Applied Mathematics and Statistics, 9.
- Morris聽CJ,听搁辞丑苍听闯尝, Glickman聽S, Mansfield聽KJ聽(2023). 聽Pathogens, 12 (3).
- 厂补迟丑颈补苍补苍迟丑补尘辞辞谤迟丑测听厂, Florman聽K, Richard聽D, Cheng聽KK, Torri聽V, McCaig聽F, Harber聽M聽&聽搁辞丑苍听闯尝听(2022). . Transplant Direct. 2023 Jan 6;9(2):e1418.
- 础测诲辞驳诲耻听惭翱, 搁辞丑苍听闯尝,听Jafari, NV, et al听(2022). . Advanced Science.
- 闯补蹿补谤颈听狈痴, 搁辞丑苍听闯尝听(2022). . Mucosal Immunology, 15, 1127-1142.
- Tandogdu聽Z, Collins聽J, Shaw聽G, 搁辞丑苍听闯尝, et al听(2021). . BJU Int. 2021 Jun;127(6):729-741.
- 惭耻谤谤补测听叠翱, 贵濒辞谤别蝉听颁, Williams聽C, Flusberg聽DA, Marr聽EE, Kwiatkowska聽KM聽... 搁辞丑苍听闯尝听(2021). . Front Cell Infect Microbiol. 2021 May 26;11:691210.
- Kasivisvanathan聽V, Lindsay聽J, Rakshani-Moghadam聽S, Elhamshary聽A聽... Rohn, JL, et al (2020). . International Journal of Surgery, 84 57-65.
- 颁辞濒濒颈苍蝉听尝, 厂补迟丑颈补苍补苍迟丑补尘辞辞谤迟丑测听厂, 搁辞丑苍听闯尝, Malone-Lee, J听(2020). .聽Int Urogynecol J, Jun;31(6):1255-1262.
- 尝补耻听奥, 搁辞丑苍听闯尝, 顿丑补谤尘补蝉别苍补听顿, Horsley聽H, 闯补蹿补谤颈听狈听...听搁辞丑苍听闯尝听(2020). . Journal of Controlled Release,听Dec 10;328:490-502.
- King聽JS, Humphreys聽D, 搁辞丑苍听闯尝, et al听(2020). . Cellular Microbiology, e13248.
- 贬耻产产补谤诲听础罢惭, 闯补蹿补谤颈听狈痴, Feasey聽N, 搁辞丑苍听闯尝, Roberts聽AP听(2019). . Frontiers in Microbiology, 10.
- Katsakouli聽C, Jiang聽X, Lau WK, 搁辞丑苍听闯尝, Edirisinghe聽M听(2019). . ACS Omega, 4 (1), 2225-2233.
- 搁辞丑苍听闯尝, Mostowy聽S, King聽JS, et al. (2019). .聽Cell Microbiol, e13081.
- Horsley H, Owen聽J, Carugo聽D, Malone-Lee聽J, Stride聽E, 搁辞丑苍听闯尝听(2019). . Journal of Controlled Release, 301, 166-175.
- 厂补迟丑颈补苍补苍迟丑补尘辞辞谤迟丑测听厂, Malone-Lee聽J, Gill聽K, Tymon聽A听...听搁辞丑苍听闯尝 (2019).听. J Clin Microbiol,听57(3):e01452-18.
- Horsley聽H, 顿丑补谤尘补蝉别苍补听顿, Malone-Lee聽J,听搁辞丑苍听闯尝 (2018). . 1238 Scientific Reports.
Funding and Partnerships
Collaborators
- Prof Eleanor Stride, Institute of Biomedical Engineering, University of Oxford
- Dr Dario Carugo, Institute of Biomedical Engineering, University of Oxford
- Dame Fiona Powrie, Kennedy Institute of Rheumatology, University of Oxford
- Prof Jamie Davies, Centre for Discovery Brain Sciences, University of Edinburgh
- Prof Meriem El Karoui, Centre for Synthetic and Systems Biology, University of Edinburgh
- Prof Mohan Edirisinghe, Department of Mechanical Engineering, 白小姐论坛
- Prof Francois Balloux, Genetics Institute, 白小姐论坛
- Dr Lucy Van Dorp, Genetics Institute, 白小姐论坛 Prof Rik Bryan, University of Birmingham
- Prof Mark Linch, 白小姐论坛 Cancer Institute, and Consultant Medical Oncologist, 白小姐论坛H
- Dr Ruth Bowness, Department of Mathematical Sciences, Univeristy of Bath
- Mr John Hines, Consultant Urological Surgeon, 白小姐论坛H
- Dr Brett Eisenberg, The Charles Stark Draper Laboratory, Boston USA
- Dr Adam Roberts, Liverpool School for Tropical Medicine.
Related programmes
Our members contribute to the MBBS, iBSc, BSc and master's degrees within the Division of Medicine. We provide BSc, iBSc and MSc/MRes research project supervision. We also have an established track record in providing high-quality training to PhD students interested in basic, translational, and clinical research in urological biology.
Contact
Professor聽Jennifer Rohn
j.rohn@ucl.ac.uk
Twitter / X: @jennyrohn
Professor Reza Motallebzadeh
r.motallebzadeh@ucl.ac.uk
Twitter / X: @rezamotallebov