IPLS Seminar: Dr Lucia Marucci (University of Bristol)
24 January 2024, 11:00 am–12:00 pm
Title: Programming cells using whole-cell modelling and feedback control
Event Information
Open to
- All
Organiser
-
Alexander Fedorec
Location
-
2nd Floor Seminar Room (2.30), LMCBMRC BuildingGower StreetLondonWC1E 6BT
Abstract: The ability to program ad hoc cells and biological processes offers exciting opportunities in basic research, in the biotechnology industry and in the clinic. Computer-aided design can significantly accelerate design-build-test-learn cycles for cellular programming; however, the lack of established design tools which can cover biological functions across scales, and difficulties in engineering systems resilient to changes and perturbations, still represent major roadblocks. Â
In this talk, I will present two complementary approaches to rationally and robustly program cell phenotypes. Â
I will first discuss how computer-aided cell design can be supported by whole-cell models (WCMs), which are mathematical models aimed at capturing the function of all genes and multiscale processes within a cell. The design of minimal bacterial genomes will be used as a proof-of-concept; I will also show how machine learning can support WCMs’ output interpretation and solve their computational burden challenge. Â
The second approach leverages feedback control to engineer robust cellular phenotypes. I will show results obtained using intracellular, external or multicellular controllers in both bacterial and mammalian cells, and diverse applications of cybergenetics methodologies (e.g., control-based analysis of gene networks’ dynamics, and drug combination therapy design). Â
Our tools and results will assist the engineering of complex biological processes, bridging the gap between the design and the implementation of robust cellular phenotypes.Â
Host:Â Alexander Fedorec
About the Speaker
Dr Lucia Marucci
at University of Bristol