The Facility provides analytical services for measurements of organic compounds, biochemical compounds and organo-metallic compounds.
In order to submit samples you must be registered as a user.
The registration and an introduction to mass spectrometry facility session are held every Tuesday and Thursday at 11 am in LG11.Ìý
There is no need for a preliminary arrangement.ÌýÌý
Routine mass spectrometry analyses:-
- Accurate mass measurements using aÌýHESI-ASAP probe in positive and negative modes. Mass range m/z 50-1,000 Da.
- Low resolution mass measurements with EI or CI (ammonia or methane).Ìý CI is in positive and negative mode. Mass range m/z 10 - 1,000 Da.
- MALDI analysis
- CapLC-MS analysis on bio-conjugated protein/peptide. Mass range m/z 1,000-6,000 Da. This LC-MS analysis normally becomes routine after discussion/establishingÌýwith the mass spectrometry staff of the sample preparation protocol and the required amount of proteinÌýfor LC-MS analysis.
Sample submission information
To submit a sample, please fill out the Sample Submission formÌýand sendÌýit with the sample to:-Ìý
°×С½ãÂÛ̳ Chemistry Mass Spectrometry Facility
Christopher Ingold Building
°×С½ãÂÛ̳ Chemistry Department
20 Gordon Street
London WC1H 0AJ
You could bring your samples by person to LG11, Basement, °×С½ãÂÛ̳ Chemistry Department and place into the tray located outside of the mass spectrometry laboratory.
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The ionisation techniques available in the facility are EI,ÌýMALDI, HESI-ASAP, ESIÌýat present.ÌýAccurate mass measurements using a heatedÌýelectrospray (HESI)-ASAP probe is preferred laboratory method and is attempted for all compounds submitted to the facility. Other techniques will be only used if HESI-ASAP fails.Ìý
Samples should be submitted in a sample screw-cap vial (available in LG11) with a sample name.
About 0.1 mgÌýof solid is required, if liquid just a few uL, please specify a solvent at which sample is soluble on the submission form.
For users from °×С½ãÂÛ̳ Chemistry department (internal users), the grant code should be written on the submission form and the submission should be approved by a financial responsible person.
For users from other °×С½ãÂÛ̳ departments or other universities, the purchase order number must be submitted along with the samples and their submission forms.
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